Hemorrhagic cystitis (HC) is a well-documented adverse event concerning patients after transplantation of hematopoetic stem cell. This frequent complication is the result of cyclophosphamide and its metabolites activity, that do damage the mucosa of the urinary bladder. HC has high morbidity, can lead to renal complications, prolonged hospitalization, increased health-care costs, and occasionally can contribute to death. Acute HC is a diffuse infl ammatory condition of urinary bladder presenting with bleeding from bladder mucosa.